SELECT-LATE: Ashlynn

General inclusion criteria:

  1. Adults (≥ 18 and ≤ 85 years) with the final diagnosis of an acute ischemic stroke
    • in-hospital stroke admissions with fluctuating clinical symptoms for patients who presented to EVT centers within 24 hours of LKW are not eligible
  2. NIHSS ≥ 6
  3. LKW > 24 to 72 hours
  4. Baseline ≤ 1
  5. Eligible for thrombectomy and medical management
  6. Signed informed consent obtained
  7. Subject willing to comply with the protocol follow-up requirements
  8. Anticipated life expectance of at least 3 months

Imaging inclusion criteria:

  1. Proven large vessel occlusion in ICA or MCA-M1 occlusion
    • carotid occlusions can be cervical or intracranial, with or without tandem MRA lesions, as determined by MRA or CTA
  2. CT Aspects 3-10
  3. CT Perfusion ischemic core (rCBF <30%) volume ≤ 150 mL or MR Diffusion ischemic core (ADC <620×10-6 mm2/s) volume ≤ 150 mL
    • if the perfusion software at the enrolling site uses another threshold/measure to define ischemic core, please use that measure to assess ischemic core criteria.

General exclusion criteria:

  1. Current participation in another investigational interventional drug or device study
  2. Baseline platelet count <100,000/μl

Imaging exclusion criteria:

  1. Evidence of intracranial tumor (except small meningioma < 3cm), acute intracranial hemorrhage, or arteriovenous malformation
  2. Significant mass effect, defined as midline shift (>3mm) using foramen of Monro as the marker for midline instead of septum pellucidum and/or effacement of sulci in contralateral hemisphere
  3. Evidence of internal carotid artery dissection that is flow limiting or aortic dissection
  4. Intracranial stent implanted in the same vascular territory that precludes the safe deployment/removal of the neurothrombectomy device
  5. Acute symptomatic arterial occlusions in more than one vascular territory confirmed on CTA/MRA
  6. Any signs of established infarct, demarcating hypodensity and area of cerebral edema on non-contrast CT
  7. CTA ASPECTS ≥2
  8. CT Perfusion ischemic core volume >150 mL or MR Diffusion ischemic core volume >150 mL