Inclusion criteria:
- Age ≥ 18 years
- Symptomatic ICH OR ischemic stroke
- Written, informed consent by patient or surrogate
- Ability to comply with all study procedures and available for the duration of the study
Exclusion criteria:
- Secondary ICH due to trauma, vascular malformation, or tumor
- Life expectancy < 1 year
- eGFR <45
- Serum potassium greater than or equal to the upper limit of normal of the lab on the two most recent consecutive potassium levels prior to enrollment
- Known hypersensitivity to spironolactone
- Upper arm greater than 17 inches in circumference
- Pregnancy, planned pregnancy, or breastfeeding
- Currently on a mineralocorticoid-receptor antagonist and/or recommended to start a mineralocorticoid-receptor antagonist as a part of their routine clinical care at the time of study screening.
- Systolic BP >200 mmHg or diastolic BP >110 mmHg at the time of randomization
- Systolic BP <120 mmHg at the time of randomization
- Any condition which, in the judgement of the investigator, increases the risk to the patient
- History of Addison’s disease
