REDUCE: Ashlynn

Inclusion criteria:

  1. Age ≥ 18 years
  2. Symptomatic ICH OR ischemic stroke
  3. Written, informed consent by patient or surrogate
  4. Ability to comply with all study procedures and available for the duration of the study

Exclusion criteria:

  1. Secondary ICH due to trauma, vascular malformation, or tumor
  2. Life expectancy < 1 year
  3. eGFR <45
  4. Serum potassium greater than or equal to the upper limit of normal of the lab on the two most recent consecutive potassium levels prior to enrollment
  5. Known hypersensitivity to spironolactone
  6. Upper arm greater than 17 inches in circumference
  7. Pregnancy, planned pregnancy, or breastfeeding
  8. Currently on a mineralocorticoid-receptor antagonist and/or recommended to start a mineralocorticoid-receptor antagonist as a part of their routine clinical care at the time of study screening.  
  9. Systolic BP >200 mmHg or diastolic BP >110 mmHg at the time of randomization
  10. Systolic BP <120 mmHg at the time of randomization
  11. Any condition which, in the judgement of the investigator, increases the risk to the patient
  12. History of Addison’s disease