Recruitment Video

• INCLUSION CRITERIA:
  1. Age at least 18 years
  2. Intracerebral hemorrhage (ICH) (including primary intraventricular hemorrhage) confirmed by brain CT or MRI
  3. Can be randomized within 14-180 days after ICH onset
  4. Non-valvular AF (defined as atrial fibrillation or atrial flutter), documented by electrocardiography or a physician-confirmed history of AF
  5. Provision of signed and dated informed consent form by patient or legally authorized representative
  6. For females of reproductive potential: use of highly effective contraception
• EXCLUSION CRITERIA:
  1. Index event is hemorrhagic transformation of a brain infarction or hemorrhage into a tumor
  2. History of an earlier ICH within 12 months preceding index event
  3. Active infective endocarditis
  4. Clear indication for anticoagulant drugs (e.g., requires anticoagulation for DVT or PE) or antiplatelet drugs (e.g., requires aspirin or clopidogrel for recent coronary stent)
  5. Previous or planned left atrial appendage closure
  6. Clinically significant bleeding diathesis
  7. Serum creatinine ≥2.5 mg/dL
  8. Active hepatitis or hepatic insufficiency with Child-Pugh score B or C
  9. Anemia (hemoglobin <8 g/dL) or thrombocytopenia (<100 x 109/L) that is chronic in the judgment of the investigator
  10. Pregnant or breastfeeding
  11. Known allergy to aspirin or apixaban
  12. Concomitant participation in a competing trial
  13. Considered by the investigator to have a condition that precludes safe or active participation in the trial
  14. Persistent, uncontrolled systolic blood pressure (≥180 mm Hg)
  15. ICH caused by an arteriovenous malformation (AVM) that has not yet been secure 

*Patient may be enrolled if exclusion resolves within 180 days of index ICH (e.g., blood pressure is controlled, AVM secured).