Inclusion criteria:

1. Age ≥ 18 years
2. Acute ischemic stroke with radiographic evidence of occlusion of the internal carotid artery and/or middle cerebral artery on either side of the brain
3. Patient will undergoing mechanical thrombectomy for acute stroke
4. Willingness and ability to sign informed consent by patient or legally acceptable surrogate decision-maker

Exclusion criteria:

1. Bilateral arterial occlusion
2. Hemicraniectomy or other skull defect that would interfere with monitoring.
3. History of brain mass (other than meningioma)
4. Pregnancy
   • Women of child-bearing age must have a negative pregnancy test (urine or serum) prior to enrollment (which is performed as part of standard care)
5. Any other illness or condition that the investigator feels would pose a hazard to the subject from participation in the study