Clinical Trials- Quick Summary


ARCADIA: ESUS, age >45, signs of atriopathy (p wave terminal force >5000, BNP >250, or LA size index on TTE >3, within 3 to 180 days from stroke onset, randomized to aspirin versus apixaban

ASPIRE: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and AF.

BAF312: study of BAF312 in hemorrhage to study efficacy, safety and tolerability.  BAF312 is a drug that could potentially limit brain inflammation after ICH and thereby improve outcomes for hemorrhage patients, Age 18 to 80 years, spontaneous, supratentorial intracerebral hemorrhage in deep brain structures with a volume of 10-30 ml, less than 24 hours from last known normal

AXIOMATIC/BMS: Phase 2, double blind study of BMS-986177 (oral factor XIa Inhibitor) for stroke prevention. Factor XIa inhibition has the potential to reduce thrombin generation enough to prevent vascular occlusion and embolism without impairing hemostasis. Patients age ≥40, w/in 48 hrs of symptom onset of stroke/TIA,  Stroke: ischemic, nonlacunar, NIHSS<5, pre-stroke mRS<3, TIA: neuro deficit, no infarct on MRI, ABCD2 >6 or motor symptoms; CanNOT have had more than 300mg of clopidogrel prior to randomization.

CHARM: Study to evaluate the efficacy and safety of intravenous glibenclamide for severe cerebral edema following large hemispheric infarction, large MCA strokes (defined as 80 to 300 cm^3 on MRI or CTP or an ASPECTS score of 1 to 5), NIHSS >10, study treatment infusion within 10 hours of symptom onset or last known normal

MOST: primary objective of the MOST trial is to determine if argatroban or eptifibatide results in improved 90-day modified Rankin scores (mRS) as compared with placebo in AIS patients treated with 0.9mg/kg IV rt-PA within three hours of symptom onset. Patients may also receive endovascular thrombectomy per usual care.

SATURN: To determine the effects of continuation vs. discontinuation of statins on the risk of ICH recurrence during 24 months of follow-up in patients presenting with a spontaneous lobar lCH while taking a statin drug. Specifically, we wish to determine the effects of discontinuing vs. continuing statins on the risk of recurrent symptomatic ICH. We hypothesize that discontinuation of statins in patients with lobar ICH is likely associated with reduced risk of ICH recurrence.

SLEEPSMART: The primary goals of this study are to determine whether treatment of OSA with positive airway pressure starting shortly after acute
ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event,
and (2) improves stroke outcomes at 3 months in patients who
experienced an ischemic stroke.

TIMELESS: Study to evaluate the efficacy and safety of tenecteplase vs placebo in AIS who present in the 4.5-24hr time window with ICA/MCA: M1/M2 occlusion.  Ages >18, prestroke mRS<2, NIHSS >5


ARCADIA: ESUS, age >45, signs of atriopathy (p wave terminal force >5000, BNP >250, or LA size index on TTE >3, within 3 to 180 days from stroke onset, randomized to aspirin versus apixaban

CREST-2: Carotid revascularization and medical management for asymptomatic carotid stenosis, patient must be greater than 35 with stenosis >70% by catheter angiography or US with >70% stenosis plus CTA/MRA >70% stenosis, end diastolic velocity >100 or internal carotid/common carotid artery peak systolic velocity ratio >4, no medical history of stroke or TIA ipsilateral to the stenosis in last 180 days, Rankin scale of  0 or 1

CREST-H: to assess cognitive outcomes in a subset of CREST-2 patients with cerebral hypoperfusion and cognitive impairment, comparing those who get revascularized versus those who get intensive medical management alone

SELECT: Semaglutide effects on cardiovascular outcomes in people with overweight or obesity, age >45, BMI >27 and prior MI, prior stroke (ischemic or hemorrhagic), or PAD, must wait at least 60 days post stroke


COMETS: ICA or M1 thrombectomy, measuring cerebral blood flow before and after thrombo

DISCOVER: TCDs in older patients who received 7T MRI to look for R to L shunt & impaired cerebral vasoreactivity

DOMINO: Anterior circulation unilateral stroke within 72 hours- Study measuring the effect of inhaled nitric oxide on cerebral blood flow.  Cannot have heart failure with severely reduced EF.

SLAM: Patients with ischemic stroke with unilateral weakness, NIHSS >1 (including limb weakness), Control patients include: TIA with negative MRI and normal exam OR EMU patients with normal MRI and exam

THORNHILL STUDY: Moderate or severe MCA stenosis, measuring CVR in the setting of MCA stenosis, one time MRI Study (MRI will be done as outpatient)